Diagnósticos e tratamentos de kernicterus / diagnostic and treatment of kernicterus

Kernicterus and prematurity.

At one time kernicterus was most commonly associated with haemolytic disease of the newborn. With the introduction of adequate exchange transfusions this complication, whether due to Rh or to ABO incompatibility, has been virtually eliminated. In 1950 two groups of workers, Aidin, Corner and Tovey in this country and Zuelzer and Mudgett in America, independently drew attention to the fact that ...

Kernicterus: Past, Present, and Future

MR findings in kernicterus.

We describe the MR appearance of kernicterus (bilirubin encephalopathy). T2-weighted images show high signal bilaterally in the globus pallidus, a known area of cerebral deposition of bilirubin.

Unbound bilirubin: a better predictor of kernicterus?

The peroxidase method described in this paper measures non–protein-bound bilirubin by oxidation of the free fraction. The oxidation rate is slow compared with rapid dissociation of albumin-bound bilirubin. Thus, the unbound bilirubin can be estimated from the initial rate of decline in total bilirubin concentration. In the 1970s, severe neonatal hyperbilirubinemia and kernicterus were major cli...

Studies on the Pathogenesis of Kernicterus

Kernicteric pigment was extracted by means of chloroform from the brains of 3 infants. Solutions of it gave a positive diazo reaction, and, as determined electrophotometrically, gave maximum absorption of light having a wavelength of 425 mmicro, being identical in these properties with chloroform solutions of crystalline mesobilirubin. Experimental kernicterus was regularly induced by injecting...